Ligands for E3 Ligase

Ligase

E3 ligase-recruiting Moiety

Ligands for E3 Ligase

Ligands for E3 Ligase Isoform Specific Products:

Ligands for E3 Ligase Isoform Comparison

Ligands for E3 Ligase Related Products (344)
Antibodies (2)
Related Compound Screening Libraries (1)
Ligands for E3 Ligase Isoform Comparison

By Effects:	Controls (2) Ligands (3) Inhibitors (2) Degraders (2) Modulators (3) Chemicals (2)

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-128808

cIAP1 ligand 1	2095244-42-9	99.90%
cIAP1 ligand 1 is the LCL161 derivative based IAP ligand. cIAP1 ligand 1 can be connected to the ABL ligand for protein by a linker to form SNIPER.

HY-128837

Nutlin carboxylic acid	2249750-27-2	98.63%
Nutlin carboxylic acid (MDM2 ligand 1) is the Nutlin 3-based MDM2 ligand. Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTAC.

HY-156106

VHL-IN-1	3033117-53-9	99.78%
VHL-IN-1 (compound 30) is a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor (dissociation constant Kd=37 nM) that stabilizes and induces HIF-1α transcriptional activity. VHL-IN-1 has potential as a HIF-1α stabilizer and degrader of proteolytically targeted chimeras (PROTACs).

HY-149934

DCAF1 binder 1	3053860-67-3	99.12%
DCAF1 binder 1 is a selective for the CRL4 DCAF1 E3 ligase complex. DCAF1 binder 1 is a ligands for E3 Ligase, involving in targeted protein degradation (TPD).

HY-133045

VHL Ligand 8	2701565-76-4	98.04%
VHL Ligand 8 is a VHL ligand. VHL Ligand 8 can be used to synthesize ARD-266 (HY-133020), a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC₅₀ values of 0.2-1 nM.

HY-143346

CCW16	2361138-33-0	98.73%
CCW16 is a cofactor for the synthesis of protein degraders, such as PROTACs CCW 28-3 (HY-156774).

HY-139539

Thalidomide-5-COOH	1216805-11-6	99.97%
Thalidomide-5-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-COOH can be connected to the ligand for protein by a linker to form PROTACs.

HY-153698

CC-3060	444288-86-2	99.7%
CC-3060 is a Cereblon modulator that promotes ZBTB16 degradation. CC-3060 degrades ZBTB16 with a DC₅₀ of 0.47 nM in HT-1080 cells. CC-3060 targets ZBTB16 for degradation by primarily engaging distinct structural degrons on different zinc finger domains.

HY-W093272

Thalidomide-5,6-F	1496997-41-1	99.84%
Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs.

HY-111663

VL285	1448188-57-5	98.84%
VL285 is a potent VHL ligand with an IC₅₀ of 0.34 μM.

HY-159646

BMS-986397	2564486-44-6	99.76%

HY-114406

TD-106	2250288-69-6	99.81%
TD-106 is a cereblon (CRBN) modulator, which can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation.

HY-131385

KB02-COOH	2375196-30-6	99.39%
KB02-COOH is a fragment of synthesis of ubiquitin E3 ligase ligand KB02. KB02 can be used in the synthesis of PROTAC, such as KB02-JQ1 (HY-129917) and KB02-SLF (HY-129610).

HY-W761299

PD 4'-oxyacetic acid	2633633-12-0	99.69%
PD 4'-oxyacetic acid is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC Degrader development.

HY-42424A

(S,R,S)-AHPC-Me dihydrochloride	2504950-56-3	99.84%
(S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC₅₀ <1 nM.

HY-138881

Lenalidomide-6-F	2468780-87-0	99.63%
Lenalidomide-6-F is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-6-F can be connected to the ligand for protein by a linker to form PROTAC.

HY-123109

(S,R,S)-AHPC-Boc	1448189-98-7
(S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Boc is used in PROTAC technology.

HY-150803

VHL Ligand 14	2010986-87-3	99.93%
VHL Ligand 14 (Compound 11) is a VHL ligand for design of PROTAC estrogen receptor α (ERα) degraders, with a binding affinity IC₅₀ of 196 nM.

HY-W076696

3-(4-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione	1061604-41-8	98.57%
Lenalidomide-4-OH is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-OH can be connected to the ligand for protein by a linker to form PROTAC.

HY-130845A

AR antagonist 1 hydrochloride	1818885-55-0	99.53%
AR antagonist 1 (compound 29) hydrochloride is a potent androgen receptor (AR) antagonist and binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266 (HY-133020).

E3 Ligase Ligand Library

Compound library containing several ligands for E3 ligase.

71compounds HY-L128

Lenalidomide			Cereblon								99.95%
Pomalidomide			Cereblon								99.96%
CC-885			Cereblon Cereblon								99.85%
Eragidomide			Cereblon								99.86%
N-Me-Thalidomide 4-fluoride			Cereblon Cereblon								99.41%
CRBN ligand-109			Cereblon								≥98.0%
Iberdomide			Cereblon Cereblon								99.54%
PT-179			Cereblon Cereblon								99.91%
VH-298	VHL										99.78%
VH032	VHL										99.64%
(S,R,S)-AHPC-Me hydrochloride	VHL										99.59%
(S,R,S)-AHPC	VHL										99.13%
(S,R,S)-AHPC monohydrochloride	VHL										99.83%
Golcadomide			Cereblon
E3 ligase Ligand 32	VHL										99.95%
Lenalidomide hemihydrate			Cereblon								99.98%
(S,R,S)-AHPC-Me	VHL										99.48%
ALV2			Cereblon Cereblon								98.07%
Lenalidomide-Br			Cereblon								99.86%
BC-1215						Fbxo3					99.93%
ALV1			Cereblon								98.62%
VH032-cyclopropane-F	VHL										99.92%
ZXH-1-161			Cereblon Cereblon								98.43%
(S,S,S)-AHPC hydrochloride	VHL										99.42%
(S)-Thalidomide			Cereblon								99.52%
Lenalidomide-OH			Cereblon								99.48%
NV03										UHRF1	98.82%
VH 101, acid	VHL										98.37%
Lenalidomide-I			Cereblon Cereblon								99.90%
Biotin-Thalidomide			Cereblon								99.65%
(S,R,S)-AHPC-propargyl	VHL										99.46%
cIAP1 ligand 1				cIAP1							99.90%
Nutlin carboxylic acid		MDM2									98.63%
VHL-IN-1	VHL										99.78%
DCAF1 binder 1			Cereblon Cereblon								99.12%
VHL Ligand 8	VHL										98.04%
CCW16							RNF4				98.73%
CC-3060			Cereblon Cereblon								99.7%
VL285	VHL										98.84%
BMS-986397			Cereblon Cereblon								99.76%
TD-106			Cereblon Cereblon								99.81%
KB02-COOH			Cereblon								99.39%
PD 4'-oxyacetic acid			Cereblon Cereblon								99.69%
(S,R,S)-AHPC-Me dihydrochloride	VHL										99.84%
(S,R,S)-AHPC-Boc	VHL
VHL Ligand 14	VHL										99.93%
AR antagonist 1 hydrochloride	VHL										99.53%
CRBN modulator-1			Cereblon								98.00%
2-Methoxyphenyl dihydrouracil			Cereblon
CC-17369			Cereblon								98.68%
(R,S,S)-VH032	VHL
Pomalidomide-5-OH			Cereblon								99.46%
E3 ligase Ligand 23			Cereblon								99.71%
Lenalidomide-F			Cereblon								99.89%
Thalidomide (Standard)			Cereblon Cereblon
VH 101, thiol	VHL										98.66%
Lenalidomide 5'-piperazine			Cereblon Cereblon								99.92%
CRBN ligand-9			Cereblon Cereblon								≥98.0%
Thalidomide-piperazine hydrochloride			Cereblon								98.27%
Pomalidomide-d₃			Cereblon Cereblon								≥99.0%
VL285 Phenol	VHL										98.56%
OICR-8268			Cereblon Cereblon
Lenalidomide (Standard)			Cereblon Cereblon
E3 ligase Ligand 18			Cereblon								99.22%
Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride			Cereblon Cereblon
Thalidomide-pyrrolidine hydrochloride			Cereblon Cereblon								≥98.0%
Cereblon inhibitor 1			Cereblon								99.19%
Thalidomide-d₄			Cereblon								98.00%
Lenalidomide-d₅			Cereblon Cereblon								99.32%
E3 ligase Ligand 8				IAP IAP							99.32%
Cereblon inhibitor 2			Cereblon Cereblon								98.86%
VH032 thiol	VHL
Pomalidomide-6-OH			Cereblon								98.09%
Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride			Cereblon Cereblon								98.08%
CRBN ligand-13			Cereblon
(R)-Thalidomide			Cereblon								99.80%
Lenalidomide hydrochloride			Cereblon
Pomalidomide-d₄			Cereblon Cereblon
(S,R,S)-AHPC TFA	VHL
Aster-A Ligand-3			Cereblon
E3 ligase Ligand 26			Cereblon
E3 ligase Ligand 42			Cereblon
E3 ligase Ligand 22			Cereblon
Pomalidomide-5-O-CH3			Cereblon
E3 ligase Ligand 10				IAP IAP
DA-PROTAC	VHL
(4R,5S)-Nutlin carboxylic acid		MDM2
PROTAC CRBN ligand-2			Cereblon
Thalidomide-(2)piperidine			Cereblon Cereblon
HOXB7 8–25		MDM2
E3 ligase Ligand 14				IAP IAP
E3 ligase Ligand 48			Cereblon
E3 ligase Ligand 38			Cereblon
CRBN ligand-17			Cereblon
Lenalidomide-¹³C₅,¹⁵N			Cereblon Cereblon
E3 ligase Ligand 57			Cereblon
(S,R,R)-VH032	VHL
E3 ligase Ligand 37	VHL
E3 ligase Ligand 36	VHL
E3 ligase Ligand PG			Cereblon, IC₅₀: 2.191 μM
(S,R,S)-AHPC-Ala	VHL
Pomalidomide-piperazine			Cereblon Cereblon
Bestatin-amido-Me				cIAP1
E3 ligase Ligand 31			Cereblon
Cyclopropane-(S,R,S)-AHPC	VHL
E3 ligase Ligand 44	VHL
cis VH-298	VHL
E3 ligase Ligand 27	VHL
VH032 analogue-2	VHL
E3 ligase Ligand 25			Cereblon
(S)-Deoxy-thalidomide-Br			Cereblon
Acepromazine-OTs			Cereblon
E3 ligase Ligand 21			Cereblon
VH032-CH2-Boc	VHL
(S)-Deoxy-thalidomide			Cereblon Cereblon
MV-1-NH-Me				cIAP1
E3 ligase Ligand 13				IAP IAP
(R)-Pomalidomide-pyrrolidine			Cereblon Cereblon
(S,R,S,R)-AHPC-Me	VHL
CRBN ligand-11			Cereblon
Thalidomide-azetidine-CHO			Cereblon Cereblon
MY-11B									DCAF1
Ru-Poma			Cereblon Cereblon
E3 ligase Ligand 45	VHL
VH032 analogue-1	VHL
BCL-xL/BCL-2 ligand 1	VHL
HL389			Cereblon
(3S)Lenalidomide-5-Br			Cereblon
VH032-NH-CO-CH2-NHBoc	VHL
GNE7599	VHL
tDHU, acid			Cereblon Cereblon								98.83%
Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride			Cereblon Cereblon
E3 ligase Ligand 34	VHL
Me-SJ46411	VHL
MEL23		MDM2
OICR-8268-acrylic acid	VHL
RR-11055			Cereblon Cereblon
N-Boc-SBP-0636457-OH				cIAP1
E3 ubiquitin ligase binder-1			Cereblon Cereblon
Thalidomide-methylpyrrolidine			Cereblon Cereblon
SJF-0661	VHL
(S,R,S)-AHPC-Ac	VHL
Pomalidomide-d₅			Cereblon Cereblon
E3 ligase Ligand 33	VHL
(S,R,S)-AHPC-O-CF3	VHL
(S,R,S)-AHPC dihydrochloride	VHL
E3 ligase Ligand 35	VHL
SJ46411-Br	VHL
E3 ligase Ligand 43	VHL
E3 ligase Ligand 7								DCAF11
E3 ligase Ligand 41			Cereblon
AS1411-C4-VH032		MDM2
VHL-SF2	VHL
cIAP1 ligand 2				cIAP1
L321			Cereblon
CRBN ligand-1			Cereblon Cereblon
Pomalidomide-¹⁵N,¹³C₅			Cereblon Cereblon
cIAP1 ligand 4				IAP IAP
Pomalidomide-6-O-CH3			Cereblon
E3 ligase Ligand 29	VHL
SOS1 Ligand intermediate-2	VHL
CRBN ligand-181			Cereblon
CRBN ligand-111			Cereblon
CRBN ligand-76			Cereblon
CRBN ligand-148			Cereblon
CRBN ligand-14			Cereblon
AR antagonist 1	VHL
CRBN ligand-183			Cereblon
CRBN ligand-110			Cereblon
CRBN ligand-63			Cereblon
3-(5-Bromo-2-chlorophenyl)piperidine-2,6-dione			Cereblon
CRBN ligand-164			Cereblon
CRBN ligand-162			Cereblon
BWA-522 intermediate-1			Cereblon Cereblon								99.27%
3-(4-Bromo-2-chlorophenyl)piperidine-2,6-dione			Cereblon
Pomalidomide (Standard)			Cereblon Cereblon
Phenyl-glutarimide 4'-oxyacetic acid			Cereblon Cereblon
CRBN ligand-45			Cereblon
SJ6145					KLHDC2
CRBN ligand-112			Cereblon
CRBN ligand-74			Cereblon
CRBN ligand-16			Cereblon
CRBN ligand-84			Cereblon
E3 ligase Ligand 30	VHL
Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph	VHL
CRBN ligand-47			Cereblon
(S,R,S)-AHPC(Me)-amido-C2-acid	VHL
CRBN ligand-83			Cereblon
3-(4-Bromo-2-fluorophenyl)piperidine-2,6-dione			Cereblon
SOS1 Ligand intermediate-1	VHL
CRBN ligand-108			Cereblon
Thalidomide-5-piperazine			Cereblon Cereblon

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Ligands for E3 Ligase

Ligands for E3 Ligase

Ligands for E3 Ligase Isoform Specific Products:

Ligands for E3 Ligase Isoform Specific Products:

Ligands for E3 Ligase Related Products (344)

Antibodies (2)

Related Compound Screening Libraries (1)

Ligands for E3 Ligase Isoform Comparison

Ligands for E3 Ligase Related Products (344):